Segmentation of post-operative glioblastoma multiforme (GBM) is essential for the planning of Tumor Treating Fields (TTFields) treatment and other clinical applications. Recent methods developed for pre-operative GBM segmentation perform poorly on post-operative GBM MRI scans. In this paper we present a method for the segmentation of GBM in post-operative patients. Our method incorporates an ensemble of segmentation networks and the Kullback–Leibler divergence agreement score in the objective function to estimate the prediction label uncertainty and cope with noisy labels and inter-observer (...) variability. Moreover, our method integrates the surgery type and computes non-tumorous tissue delineation to automatically segment the tumor. We trained and validated our method on a dataset of 340 enhanced T1 MRI scans of patients that were treated with TTFields (270 scans for train and 70 scans for test). For validation, we developed a tool that uses the uncertainty map along with the segmentation result. Our tool allows visualization and fast editing of the tissues to improve the results dependent on user preference. Three physicians reviewed and graded our segmentation and editing tool on 12 different MRI scans. The validation set average (SD) Dice scores were 0.81 (0.11), 0.71 (0.24), 0.64 (0.25), and 0.68 (0.19) for whole-tumor, resection, necrotic-core, and enhancing-tissue, respectively. The physicians rated 72% of the segmented GBMs acceptable for treatment planning or better. Another 22% can be edited manually in a reasonable time to achieve a clinically acceptable result. According to these results, the proposed method for GBM segmentation can be integrated into TTFields treatment planning software in order to shorten the planning process. To conclude, we have extended a state-of-the-art pre-operative GBM segmentation method with surgery-type, anatomical information, and uncertainty visualization to facilitate a clinically viable segmentation of post-operative GBM for TTFields treatment planning. (shrink)

The ever-increasing application of algorithms to decision-making in a range of social contexts has prompted demands for algorithmic accountability. Accountable decision-makers must provide their decision-subjects with justifications for their automated system’s outputs, but what kinds of broader principles should we expect such justifications to appeal to? Drawing from political philosophy, I present an account of algorithmic accountability in terms of the democratic ideal of ‘public reason’. I argue that situating demands for algorithmic accountability within this justificatory framework enables us to (...) better articulate their purpose and assess the adequacy of efforts toward them. (shrink)

Business and Society Review, Volume 127, Issue S1, Page 193-222, Spring 2022.

The #1bestseller that presents a funny, honest, and engaging look at the craziness of modern life, explaining why we're all just a little bit out of our minds. In Sane New World, Ruby Wax - comedian, writer and mental health advocate - shows us just how our minds can send us mad as our internal critics play on a permanent loop tape. 'Don't do that.. why you... you didn't... should have... but you didn't...'. Ruby knows those voices well. (...) She has been on a tough but ultimately enlightening journey that has taken her from battling depression to achieving a Masters Degree from Oxford University in Mindfulness-based Cognitive Therapy. In Sane New World, Ruby helps us all understand why we sabotage our sanity, how our brains work and how we can rewire our thinking - often through simple mindfulness techniques - to find calm in a frenetic world. (shrink)

This book attempts to bridge the gulf that still exists between 'literary' and 'philosophical' interpreters of Plato by looking at his use of characterization. Characterization is intrinsic to dramatic form and a concern with human character in an ethical sense pervades the dialogues on the discursive level. Form and content are further reciprocally related through Plato's discursive preoccupation with literary characterization. Two opening chapters examine the methodological issues involved in reading Plato 'as drama' and a set of questions surrounding Greek (...) 'character' words, including ancient Greek views about the influence of dramatic character on an audience. The figure of Sokrates qua Platonic 'hero' also receives preliminary discussion. The remaining chapters offer close readings of select dialogues, chosen to show the wide range of ways in which Plato uses his characters, with special emphasis on the kaleidoscopic figure of Sokrates and on Plato's own relationship to his 'dramatic' hero. (shrink)

Kim’s causal exclusion argument purports to demonstrate that the non-reductive physicalist must treat mental properties (and macro-level properties in general) as causally inert. A number of authors have attempted to resist Kim’s conclusion by utilizing the conceptual resources of Woodward’s interventionist conception of causation. The viability of these responses has been challenged by Gebharter, who argues that the causal exclusion argument is vindicated by the theory of causal Bayesian networks (CBNs). Since the interventionist conception of causation relies crucially on CBNs (...) for its foundations, Gebharter’s argument appears to cast significant doubt on interventionism’s anti-reductionist credentials. In the present article, we both (1) demonstrate that Gebharter’s CBN-theoretic formulation of the exclusion argument relies on some unmotivated and philosophically significant assumptions (especially regarding the relationship between CBNs and the metaphysics of causal relevance), and (2) use Bayesian networks to develop a general theory of causal inference for multi-level systems that can serve as the foundation for an anti-reductionist interventionist account of causation.1. (shrink)

Platonism is the most pervasive philosophy of mathematics. Indeed, it can be argued that an inarticulate, half-conscious Platonism is nearly universal among mathematicians. The basic idea is that mathematical entities exist outside space and time, outside thought and matter, in an abstract realm. In the more eloquent words of Edward Everett, a distinguished nineteenth-century American scholar, "in pure mathematics we contemplate absolute truths which existed in the divine mind before the morning stars sang together, and which will continue to exist (...) there when the last of their radiant host shall have fallen from heaven." In What is Mathematics, Really?, renowned mathematician Rueben Hersh takes these eloquent words and this pervasive philosophy to task, in a subversive attack on traditional philosophies of mathematics, most notably, Platonism and formalism. Virtually all philosophers of mathematics treat it as isolated, timeless, ahistorical, inhuman. Hersh argues the contrary, that mathematics must be understood as a human activity, a social phenomenon, part of human culture, historically evolved, and intelligible only in a social context. Mathematical objects are created by humans, not arbitrarily, but from activity with existing mathematical objects, and from the needs of science and daily life. Hersh pulls the screen back to reveal mathematics as seen by professionals, debunking many mathematical myths, and demonstrating how the "humanist" idea of the nature of mathematics more closely resembles how mathematicians actually work. At the heart of the book is a fascinating historical account of the mainstream of philosophy--ranging from Pythagoras, Plato, Descartes, Spinoza, and Kant, to Bertrand Russell, David Hilbert, Rudolph Carnap, and Willard V.O. Quine--followed by the mavericks who saw mathematics as a human artifact, including Aristotle, Locke, Hume, Mill, Peirce, Dewey, and Lakatos. In his epilogue, Hersh reveals that this is no mere armchair debate, of little consequence to the outside world. He contends that Platonism and elitism fit well together, that Platonism in fact is used to justify the claim that "some people just can't learn math." The humanist philosophy, on the other hand, links mathematics with geople, with society, and with history. It fits with liberal anti-elitism and its historical striving for universal literacy, universal higher education, and universal access to knowledge and culture. Thus Hersh's argument has educational and political ramifications. Written by the co-author of The Mathematical Experience, which won the American Book Award in 1983, this volume reflects an insider's view of mathematical life, based on twenty years of doing research on advanced mathematical problems, thirty-five years of teaching graduates and undergraduates, and many long hours of listening, talking to, and reading philosophers. A clearly written and highly iconoclastic book, it is sure to be hotly debated by anyone with a passionate interest in mathematics or the philosophy of science. (shrink)

Human uterus transplantation is currently under investigation as a treatment for uterine infertility. Without a uterus transplant, the options available to women with uterine infertility are adoption or surrogacy; only the latter has the potential for a genetically related child. UTx will offer recipients the chance of having their own pregnancy. This procedure occurs at the intersection of two ethically contentious areas: assisted reproductive technologies and organ transplantation. In relation to organ transplantation, UTx lies with composite tissue transplants such as (...) face and limb grafts, and shares some of the ethical concerns raised by these non-life saving procedures. In relation to ART, UTx represents one more avenue by which a woman may seek to meet her reproductive goals, and as with other ART procedures, raises questions about the limits of reproductive autonomy. This paper explores the ethical issues raised by UTx with a focus on the potential gap between women's desires and aspirations about pregnancy and the likely functional outcomes of successful UTx. (shrink)

Decisions based on algorithmic, machine learning models can be unfair, reproducing biases in historical data used to train them. While computational techniques are emerging to address aspects of these concerns through communities such as discrimination-aware data mining and fairness, accountability and transparency machine learning, their practical implementation faces real-world challenges. For legal, institutional or commercial reasons, organisations might not hold the data on sensitive attributes such as gender, ethnicity, sexuality or disability needed to diagnose and mitigate emergent indirect discrimination-by-proxy, such (...) as redlining. Such organisations might also lack the knowledge and capacity to identify and manage fairness issues that are emergent properties of complex sociotechnical systems. This paper presents and discusses three potential approaches to deal with such knowledge and information deficits in the context of fairer machine learning. Trusted third parties could selectively store data necessary for performing discrimination discovery and incorporating fairness constraints into model-building in a privacy-preserving manner. Collaborative online platforms would allow diverse organisations to record, share and access contextual and experiential knowledge to promote fairness in machine learning systems. Finally, unsupervised learning and pedagogically interpretable algorithms might allow fairness hypotheses to be built for further selective testing and exploration. Real-world fairness challenges in machine learning are not abstract, constrained optimisation problems, but are institutionally and contextually grounded. Computational fairness tools are useful, but must be researched and developed in and with the messy contexts that will shape their deployment, rather than just for imagined situations. Not doing so risks real, near-term algorithmic harm. (shrink)

Using historical documents and evidence gathered in the field, Rubie Watson provides a social history of the 600-year-old Chinese lineage village of Ha Tsuen in the New Territories of Hong Kong, and demonstrates the crucial role that the lineage played in the evolution of the community from a few scattered households in the fourteenth century into a regional power from the 1700s onwards. Despite a patrilineal ideology that extols the virtues of brotherhood and equality, Dr Watson shows that the lineage (...) has in fact played a central role in the formation, development and maintenance of an élite class of landlords and merchants, who, even though their economic importance has now declined, continue to exert political control. Dr Watson examines the dynamics of interclass relations within a single lineage and shows how these relations have been transformed as a consequence of the growth of wage labour. (shrink)

It is explained that, in the sense of the sociologist Erving Goffman, mathematics has a front and a back. Four pervasive myths about mathematics are stated. Acceptance of these myths is related to whether one is located in the front or the back.

Scholars are beginning to use the concept medicalization of poverty to theorize how the United States spends large amounts of money on illnesses related to poverty but invests much less in preventing these illnesses and the conditions that create them. This study examines the connection between poverty, disease burden and health-related costs through the in-depth interviews of 86 Black mothers living in neighborhoods with high levels of violence on the South Side of Chicago. The rippling costs of poverty and violence (...) include 56 percent of the mothers reporting post-traumatic stress disorder symptoms and 48 percent reporting mild to severe depressive symptoms. Mothers also report poor housing quality such as “toxic mold.” The physical costs include reports of back pains, stomach aches, hair falling out, panic attacks, hands shaking, insomnia, fainting from exhaustion and lack of sexual desire, and children with asthma and osteomyelitis reportedly from the exposure to mold. Transformative solutions are explored that build upon the cultural resources of Black mothers and engage policy levers. (shrink)

Early Christian writers defined idolatry around the monotheistic distinction between proper worship of the creator and vain worship of the creature, which they had inherited from Hellenistic Judaism. Despite the remarkable consensus about the validity of this theological analysis, the medieval synthesis was under severe strain throughout the early modern period, mainly because of the concept's extended range of application in the new contexts of religious controversy. In all these cases, deciding what practices constituted idolatry was open to debate. By (...) the eighteenth century, libertine writers could retain the concept of superstition at the expense of that of idolatry, which Voltaire (himself an anti-Christian deist) denounced as meaningless. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2014 Heft: 202 Seiten: 395-424.

In this paper, I use interventionist causal models to identify some novel Newcomb problems, and subsequently use these problems to refine existing interventionist treatments of causal decision theory. The new Newcomb problems that make trouble for existing interventionist treatments involve so-called ‘exotic choice’—that is, decision-making contexts where the agent has evidence about the outcome of her choice. I argue that when choice is exotic, the interventionist can adequately capture causal decision-theoretic reasoning by introducing a new interventionist approach to updating on (...) exotic evidence. But I also argue that this new updating procedure is principled only if the interventionist trades in the typical interventionist conception of choice for an alternative Ramseyan conception. I end by arguing that the guide to exotic choice developed here may, despite its name, be useful in some everyday contexts. (shrink)

There are two distinct meanings to ‘mathematical proof’. The connection between them is an unsolved problem. The first step in attacking it is noticing that it is an unsolved problem.

As the number of consumer transgressions continues to increase, so do their financial repercussions for companies. Though academic and managerial interest in addressing this issue is growing, research on how to dissuade consumers from committing transgressions remains scarce. Drawing on the mental imagery literature and normative moral theory, the present research examines a novel way of reducing consumers’ appraisals of their own transgressions. Whereas an actor-imagery perspective fosters a teleological, egoistic view of morality and, in turn, induces moral leniency, having (...) consumers adopt an observer-imagery perspective fosters a deontological view of morality and, in turn, induces moral stringency. The effects are robust across various types of consumer transgressions, including the purchase of counterfeit products and return fraud in the form of wardrobing. Study 2 also rules out vividness as an alternative explanation for these effects. Theoretical and managerial implications are discussed. (shrink)

Jim Joyce has argued that David Lewis’s formulation of causal decision theory is inadequate because it fails to apply to the “small world” decisions that people face in real life. Meanwhile, several authors have argued that causal decision theory should be developed such that it integrates the interventionist approach to causal modeling because of the expressive power afforded by the language of causal models, but, as of now, there has been little work towards this end. In this paper, I propose (...) a variant of Lewis’s causal decision theory that is intended to meet both of these demands. Specifically, I argue that Lewis’s causal decision theory can be rendered applicable to small world decisions if one analyzes his dependency hypotheses as causal hypotheses that depend on the interventionist causal modeling framework for their semantics. I then argue that this interventionist variant of Lewis’s causal decision theory is preferable to interventionist causal decision theories that purportedly generalize Lewis’s through the use of conditional probabilities. This is because Lewisian interventionist decision theory captures the causal decision theorist’s conviction that any correlation between what the agent does and cannot cause should be irrelevant to the agent’s choice, while purported generalizations do not. (shrink)

The AI world was rocked with controversy when Blake Lemoine, an AI researcher at Google claimed that their new LaMDA model was sentient. This Curmudgeon’s Corner article explores his claims critically by contrasting them to the original LaMDA paper released by the team of researchers at Google. The piece explores the human tendency for anthropomorphization via historical chatbots such as Eliza and potential reasons why we developed this propensity. It addresses the potential causes for the model’s choice of words. Subsequently, (...) using the scoring criteria of the language model, I provide an explanation for the model’s behavior in the conversation with Lemoine. Finally, I explore some of Lemoine’s assertions and break down the logical gaps they hold. I conclude on a potential reorientation of the debate in view of our unfortunate tendency. (shrink)

McGee argues that it is sometimes reasonable to accept both x and x-> without accepting y->z, and that modus ponens is therefore invalid for natural language indicative conditionals. Here, we examine McGee's counterexamples from a Bayesian perspective. We argue that the counterexamples are genuine insofar as the joint acceptance of x and x-> at time t does not generally imply constraints on the acceptability of y->z at t, but we use the distance-based approach to Bayesian learning to show that applications (...) of modus ponens are nevertheless guaranteed to be successful in an important sense. Roughly, if an agent becomes convinced of the premises of a modus ponens argument, then she should likewise become convinced of the argument's conclusion. Thus we take McGee's counterexamples to disentangle and reveal two distinct ways in which arguments can convince. Any general theory of argumentation must take stock of both. (shrink)

Although excess blood collection has characterized U.S. national disasters, most dramatically in the case of September 11, periodic shortages of blood have recurred for decades. In response, I propose a new model of medical philanthropy, one that specifically uses charitable contributions to health care as blood donation incentives. I explain how the surge in blood donations following 9/11 was both transient and disaster-specific, failing to foster a greater continuing commitment to donate blood. This underscores the importance of considering blood donation (...) incentives. I defend charitable incentives as an alternative to financial incentives, which I contend would further extend neoliberal market values into health care. I explain my model's potential appeal to private foundations or public–private partnerships as a means for expanding both the pool of blood donors and the prosocial benefit of each act of blood donation. Finally I link my analysis to the empirical literature on blood donation incentives. (shrink)

Brentano is often considered the originator of the fitting-attitudes analysis of value, on which to be valuable is to be that which it’s fitting to value. But there has been comparatively little attention paid to Brentano’s argument for this analysis. That argument advances the stronger claim that fittingness is part of the analysis of normativity. Since the argument rests on an analogy between truth and fittingness, its impact may seem limited by the idiosyncratic features of Brentano’s later notion of truth. (...) I argue, however, that the Brentanian argument is defensible even if fittingness is analogized to a more typical realist account of truth. The result is what I call the worldly Brentanian account of normativity. I defend this account as a form of naturalistic realism. I then show how the account can fare better than prominent alternatives against two kinds of error-theoretic arguments. (shrink)

The problem of the reality and nature of novelty in the universe has long engaged the attention of philosophers. “There is nothing new under the sun” is one ancient weighty utterance. On the other hand, “you cannot step twice into the same river”, said Heraclitus, for in the interval between your first and second steps, the river has changed and you have changed. One recent attempt to analyze this problem and other affiliated problems, is the theory of emergence.

Meek and Glymour use the graphical approach to causal modeling to argue that one and the same norm of rational choice can be used to deliver both causal-decision-theoretic verdicts and evidential-decision-theoretic verdicts. Specifically, they argue that if an agent maximizes conditional expected utility, then the agent will follow the causal decision theorist’s advice when she represents herself as intervening, and will follow the evidential decision theorist’s advice when she represents herself as not intervening. Since Meek and Glymour take no stand (...) on whether agents should represent themselves as intervening, they provide more general advice than standard causal decision theorists and evidential decision theorists. But I argue here that even Meek and Glymour’s advice is not sufficiently general. This is because their advice is not sensitive to the distinct ways in which agents can fail to intervene, and there are decision-making contexts in which agents can reasonably have non-extreme confidence that they are intervening. I then show that the most natural extension of Meek and Glymour’s framework fails, but offer a generalization of my “Interventionist Decision Theory” that does not suffer from the same problems. (shrink)

Bayesians standardly claim that there is rational pressure for agents’ credences to cohere across time because they face bad (epistemic or practical) consequences if they fail to diachronically cohere. But as David Christensen has pointed out, groups of individual agents also face bad consequences if they fail to interpersonally cohere, and there is no general rational pressure for one agent's credences to cohere with another’s. So it seems that standard Bayesian arguments may prove too much. Here, we agree with Christensen (...) that there is no general rational pressure to diachronically cohere, but we argue that there are particular cases in which there is rational pressure to diachronically cohere, as well as particular cases in which interpersonal probabilistic coherence is rationally required. More generally, we suggest that Bayesian arguments for coherence apply whenever a collection (of agents or time slices) has a shared dimension of value and an ability to coordinate their actions in a range of cases relevant to that value. Typically, this shared value and ability to coordinate is very strong across the time slices of one human being, and very weak across different human beings, but there are special cases where these can switch—i.e., some groups of humans will have as much reason for their beliefs to cohere across a particular range of cases as the time slices of one human usually do, but some time slices of a human will have as much freedom to differ in their beliefs from the others as the members of a group usually do. (shrink)

Ruby Meager; The Dangers of Aestheticism in Schooling, Journal of Philosophy of Education, Volume 15, Issue 1, 30 May 2006, Pages 23–30, https://doi.org/10.1111.

Ruby Meager; The Dangers of Aestheticism in Schooling, Journal of Philosophy of Education, Volume 15, Issue 1, 30 May 2006, Pages 23–30, https://doi.org/10.1111.

"This new collection of essays edited by Reuben Hersh contains frank facts and opinions from leading mathematicians, philosophers, sociologists, cognitive ...

This book is the first detailed study of the plays of Sophocles through examination of a single ethical principle--the traditional Greek popular moral code of "helping friends and harming enemies." Five of the extant plays are discussed in detail from both a dramatic and an ethical standpoint, and the author concludes that ethical themes are not only integral to each drama, but are subjected to an implicit critique through the tragic consequences to which they give rise. Greek scholars and students (...) of Greek drama and Greek thought will welcome this book, which is presented in such a way as to be accessible to specialists and nonspecialists alike. No knowledge of Greek is required. (shrink)

This work seeks to honor Michael Novak’s contribution to sport ethics by returning to his seminal work, The Joy of Sports. Novak runs an alternate route in developing his ethic, drawing largely on the school of political realism, particularly the work of Reinhold Niebuhr. In so doing, he offers a distinctive lens through which to approach to the myriad ethical issues in sport, including those related to competition, violence, and engagement in foul play. The essay outlines four core dimensions of (...) realism within Novak’s larger corpus in order to elucidate their unfolding within The Joy of Sports. It also contributes to an understanding of how political realism might be appropriated for sport ethics. (shrink)

The world flipped its sign from open to closed. I'm 6,714 miles from home in a place that tastes familiar. At night, I dream about my mother. It goes like this: I, blindfolded, frantic. My mother, always out of reach.When the sun rises, I bake bread and find I have fallen in...

In contemporary political theory, democracy embodies the ideals of the Aristotelian state, the one that is most able to realize the ideal life of the political community. Nevertheless, fledgling democracies are confronted with economic and political problems which Paul Ricœur thinks are due to the essential dissymmetry between the governing authority and the governed, culminating in the violence of the powerful agent. The enjoyment of the good life in a democracy presupposes what Ricœur calls an ethics of politics, which consists (...) in nothing other than the creation of spaces of freedom which confer on the governed a structure that enables its members to pursue the aim of enduring indefinitely in the future. When the governing authority buries into oblivion the desire of the historical community to live well with and for others in just institutions, the governed are expected to act in concert in order to ascertain their enjoyment of the good life because they feel particularly responsible for the horizontal bond that is constitutive of their will to live together. Thus, Paul Ricœur explains that the balancing of power in common and domination is an endless task of democracy that seeks to place domination under the control of power-in-common. (shrink)